Programming has become one of the most crucial skills for students in the era of IR4.0. Python, a general-purpose programming language, is often taught in classes due to its simple syntax, enabling programmers to write code with fewer lines compared to other languages. Programming with Python covers fundamental concepts such as Selection, Repetition, Functions, Strings, Files, and Databases. Each chapter includes examples of code and exercises to facilitate learning and practice. The book aims to foster insight and understanding of programming concepts, showcasing its application in various fields, including web applications, data science, artificial intelligence, and more