The history of the University of Texas MD Anderson Cancer Center Department of Gynecologic Oncology and Reproductive Medicine dates to 1947 when Felix N. Rutledge joined the institution as the first gynecologist. During this 75+ year time span, there has never been any systematic documentation of its story. This book provides a window into the lives of some of the people who established this department as the premier, world-class unit for the care of women with gynecologic cancers. In addition, it describes several of the cadre's pioneering and practice-changing contributions in clinical management, clinical and translational research, and the education of several generations of gynecologic oncologists. From its inception, this department was built on the foundation of comprehensive multidisciplinary care. As a tertiary referral center, the group has prided itself in its mission to extend advice for and management of the most challenging and complex cases. During this period, the department has transformed from a small, all-male faculty until the 1970s to a robust, diverse, multi-ethnic group of outstanding faculty and fellows in which women now comprise the majority. This paradigm shift has clearly strengthened our overall vision and mission. Dr. Rutledge's most endearing qualities were his humility and openness to opinions of others. As the department evolves, it is hoped that future generations will be inspired by his legacy and will embrace those attributes as they continue to make cancer history.