As global challenges in health and sustainability grow more complex, the integration of diverse scientific disciplines has become essential. This volume presents a curated selection of high-impact research from the International Science, Technology, and Engineering Conference (ISTEC) 2025, showcasing the latest breakthroughs at the intersection of chemistry, biology, and mathematics. Featured highlights include: (i) Environmental & Materials Innovation: New strategies for remediation and advanced material design. (ii) Life Sciences & Biotechnology: Insights into bioactive compounds and modern biotechnological applications. (iii) Computational Intelligence: In silico approaches, mathematical modelling, and the simulation of complex engineering systems. By combining theoretical frameworks with experimental data, this book provides a comprehensive roadmap for addressing contemporary challenges in system optimisation and sustainable development. An essential reference for researchers, academicians, and industry professionals, as well as undergraduate and postgraduate students seeking a deep dive into the latest interdisciplinary advances in science and technology.